文章基本信息

标题：Fiber Increases Endogenous Insulin and Reduces Insulin Resistance in Diabetes
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作者：Sunarti ; Sri Lestari Sulistyo Rini ; Dianandha Septiana Rubi 等
期刊名称：Pakistan Journal of Nutrition
印刷版ISSN：1680-5194
电子版ISSN：1994-7984
出版年度：2019
卷号：18
期号：9
页码：895-899
DOI：10.3923/pjn.2019.895.899
出版社：Asian Network for Scientific Information
摘要：Background and Objective: Dietary fibers have been identified to have beneficial effects in improving insulin secretion and insulin resistance . This study aimed to evaluate the effects of fiber-rich snacks on insulin secretion and insulin resistance in patients with type 2 diabetes mellitus (T2DM). Materials and Methods: Twenty patients with T2DM, ages 40-60 years were recruited from the Polyclinic of Endocrine, General Hospital Dr. Sardjito, Yogyakarta, Indonesia. The subjects received daily 32 g snacks made from a mixture of Dioscorea esculenta , arrowroot, cassava and pumpkin, for 4 weeks. Fasting plasma glucose , insulin and C-peptide levels were measured before and after intervention. Paired t-tests were used to evaluate the results. Results: Intervention of fiber-rich snacks for 4 weeks for T2DM patients significantly (p = 0.01) reduced fasting plasma glucose from 9.3±2.7 to 8.3±2.5 mmol L1 and homeostatic model assessment of insulin resistance (p = 0.04) from 4.1±1.3 to 3.6±1.9 and significantly (p<0.001) increased C-peptide levels from 0.417±0.004 to 0.512±0.008 ng mL1. Conclusion: In this study, fiber-rich snacks provide significant benefits to increase endogenous insulin secretion and reduce insulin resistance in patients with T2DM.
关键词：Body mass index; dietary fiber; HOMA-IR; insulin resistance index; lipid profile; snack supplement; T2DM