文章基本信息

标题：Abnormal intra-network architecture in extra-striate cortices in amblyopia: a resting state fMRI study
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作者：Zhuo Lu ; Yufeng Huang ; Qilin Lu 等
期刊名称：Eye and Vision
印刷版ISSN：2326-0254
出版年度：2019
卷号：6
期号：1
页码：1-8
DOI：10.1186/s40662-019-0145-2
出版社：BioMed Central
摘要：Amblyopia (lazy eye) is one of the most common causes of monocular visual impairment. Intensive investigation has shown that amblyopes suffer from a range of deficits not only in the primary visual cortex but also the extra-striate visual cortex. However, amblyopic brain processing deficits in large-scale information networks especially in the visual network remain unclear. Through resting state functional magnetic resonance imaging (rs-fMRI), we studied the functional connectivity and efficiency of the brain visual processing networks in 18 anisometropic amblyopic patients and 18 healthy controls (HCs). We found a loss of functional correlation within the higher visual network (HVN) and the visuospatial network (VSN) in amblyopes. Additionally, compared with HCs, amblyopic patients exhibited disruptions in local efficiency in the V3v (third visual cortex, ventral part) and V4 (fourth visual cortex) of the HVN, as well as in the PFt, hIP3 (human intraparietal area 3), and BA7p (Brodmann area 7 posterior) of the VSN. No significant alterations were found in the primary visual network (PVN). Our results indicate that amblyopia results in an intrinsic decrease of both network functional correlations and local efficiencies in the extra-striate visual networks.
关键词：Amblyopia;fMRI;Resting state;Extra-striate cortices;Visuospatial network;Graph analysis