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标题：Associated risk factors in the early stage of diabetic retinopathy
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作者：Fan Tan ; Qi Chen ; Xiran Zhuang 等
期刊名称：Eye and Vision
印刷版ISSN：2326-0254
出版年度：2019
卷号：6
期号：1
页码：1-10
DOI：10.1186/s40662-019-0148-z
出版社：BioMed Central
摘要：To investigate the retinal capillary density (RCD) of the macula using optical coherence tomography angiography (OCT-A) in type 2 diabetic patients and to further determine the association with risk factors. A total of 212 eyes from 212 subjects were recruited; subjects included diabetics with no retinopathy (NDR, n = 90 eyes), diabetics with mild retinopathy DR (MDR, n = 36 eyes), and healthy participants (Control, n = 86 eyes). All participants underwent OCT-A scanning. RCD was quantified by superficial and deep retinal capillary layers (SRCL and DRCL) from OCT-A images. RCD in SRCL and DRCL was lower in NDR (P 55y, HbA1c > 7% had significantly reduced DRCL (P 8.2 mmol/L had significantly reduced SRCL and DRCL when compared to the other group of diabetics. Risk factors including older age, higher level of HbA1c, LDL-C and BUN, were associated with lower RCDs found in type 2 diabetic patients with and without mild DR by OCT-A. The impairment of retinal capillary by OCT-A may play a key role in the early monitoring of management in diabetes.
关键词：Diabetic retinopathy;Optical coherence tomography angiography;Retinal capillary density;Systematic risk factors