文章基本信息

标题：The development of p53 tumor diagnosis and drug design strategy in its disordered region
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作者：Yiyun Zhang
期刊名称：E3S Web of Conferences
印刷版ISSN：2267-1242
电子版ISSN：2267-1242
出版年度：2019
卷号：78
页码：1-3
DOI：10.1051/e3sconf/20197801001
出版社：EDP Sciences
摘要：As a tumor suppressor protein, p53 is directly involved in the control of cell cycle arrest, which plays a crucial role in cell metabolism, growth, apoptosis and responses to different types of damage or stress processes. And since the tumor and cancer are usually related to the mutation or functional inactivation of the p53, it’s necessary to investigate the mechanism of p53 functioning the tumor and other disease, trying to figure out its drug design strategy. In this paper, a brief introduction of p53 is given, including the structure, function and properties. Subsequently, the relationship of p53 gene and cancer is also discussed. In the end, a new rational drug-design for disordered region of p53 was summarized.
其他摘要：As a tumor suppressor protein, p53 is directly involved in the control of cell cycle arrest, which plays a crucial role in cell metabolism, growth, apoptosis and responses to different types of damage or stress processes. And since the tumor and cancer are usually related to the mutation or functional inactivation of the p53, it’s necessary to investigate the mechanism of p53 functioning the tumor and other disease, trying to figure out its drug design strategy. In this paper, a brief introduction of p53 is given, including the structure, function and properties. Subsequently, the relationship of p53 gene and cancer is also discussed. In the end, a new rational drug-design for disordered region of p53 was summarized