文章基本信息

标题：Denervated muscle extract promotes recovery of muscle atrophy through activation of satellite cells. An experimental study
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作者：Eduardo Agüera ; Salvador Castilla ; Evelio Luque 等
期刊名称：Journal of Sport and Health Science
印刷版ISSN：2095-2546
出版年度：2019
卷号：8
期号：1
页码：1-9
DOI：10.1016/j.jshs.2017.05.007
出版社：Elsevier
摘要：Purpose The objective of the present study was to determine whether a denervated muscle extract (DmEx) could stimulate satellite cell response in denervated muscle. Methods Wistar rats were divided into 4 groups: normal rats, normal rats treated with DmEx, denervated rats, and denervated rats treated with DmEx. The soleus muscles were examined using immunohistochemical techniques for proliferating cell nuclear antigen, desmin, and myogenic differentiation antigen (MyoD), and electron microscopy was used for analysis of the satellite cells. Results The results indicate that while denervation causes activation of satellite cells, DmEx also induces myogenic differentiation of cells localized in the interstitial space and the formation of new muscle fibers. Although DmEx had a similar effect in nature on innervated and denervated muscles, this response was of greater magnitude in denervated vs . intact muscles. Conclusion Our study shows that treatment of denervated rats with DmEx potentiates the myogenic response in atrophic denervated muscles.
关键词：Muscle atrophy ; Muscle denervation ; Muscle extract ; Myogenic response ; Satellite cell ; Skeletal muscle