文章基本信息

标题：Mutational Screening of the Negative Regulatory Region of Astrocyte Elevated Gene -1 Promoter in Hepatocellular Carcinoma Patients
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作者：Naghmeh Gholipour ; Fatemeh Akbarian ; Hamideh Khajeh 等
期刊名称：Journal of Scientific Research and Reports
电子版ISSN：2320-0227
出版年度：2018
卷号：20
期号：6
页码：1-7
DOI：10.9734/JSRR/2018/10085
出版社：Sciencedomain International
摘要：Objective: This study is aimed to assess the correlation between negative regulatory region of AEG-1 promoter and genetic susceptibility to hepatocellular carcinoma in Iranian population. Methods: The negative regulatory region of human AEG-1 promoter was explored in 50 Iranian HCC patients. The PCR-sequencing method was used for investigating AEG-1 promoter polymorphisms. Results: This analysis did not reveal the presence of any deletions, insertions, or mutations in this region of AEG-1 promoter. Conclusion: Mutations in the negative regulatory region of AEG-1 promoter have no significant relevance with hepatocellular carcinoma. Nevertheless, to our knowledge, this is the first study to investigate the mutations of the negative regulatory region of AEG-1 promoter in HCC patient. The role of AEG-1 promoter played in HCC needs to be further studied.
关键词：Astrocyte elevated gene -1;promoter;hepatocellular carcinoma;mutation