文章基本信息

标题：Growth Inhibition of Human Breast and Prostate Cancer Cells by Cinnamic Acid Derivatives and Their Mechanism of Action
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作者：Masahiko Imai ; Hiromasa Yokoe ; Masayoshi Tsubuki 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2019
卷号：42
期号：7
页码：1134-1139
DOI：10.1248/bpb.b18-01002
出版社：The Pharmaceutical Society of Japan
摘要：Cancer is the leading cause of death and there is a particularly pressing need to develop effective treatments for breast and prostate cancer. In the current study, we show the inhibitory effects of cinnamic acid derivatives, including caffeic acid phenethyl ester (CAPE, 1 ), on the growth of breast and prostate cancer cells. Among the compounds examined, 3,4,5-trihydroxycinnamic acid decyl ester ( 6 ) showed the most potent inhibition of cancer cell growth by the induction of apoptosis. Compound 6 could be a new anti-cancer agent for use against breast and prostate cancer.
关键词：cinnamic acid;caffeic acid phenethyl ester;breast cancer;prostate cancer;apoptosis