文章基本信息

标题：Direct Formylation of Fluorine-Containing Aromatics with Dichloromethyl Alkyl Ethers
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作者：Takuya Warashina ; Daisuke Matsuura ; Yoshikazu Kimura 等
期刊名称：Chemical and Pharmaceutical Bulletin
印刷版ISSN：0009-2363
电子版ISSN：1347-5223
出版年度：2019
卷号：67
期号：6
页码：587-593
DOI：10.1248/cpb.c19-00176
出版社：The Pharmaceutical Society of Japan
摘要：Formylations of fluorine-containing aromatic compounds with dichloromethyl alkyl ethers have been investigated. Dichloromethyl propyl ether and dichloromethyl butyl ether have been applied for the formylation of fluorine-containing anisoles to give the corresponding aldehydes in good yields. Application of these ethers is preferable to that of methyl ether, which is prepared from volatile methyl formate. Reaction of fluorine-containing phenols with these dichloromethyl alkyl ethers did not give salicylaldehyde derivatives, leading instead to corresponding aryl formates in high yields. A plausible mechanism is discussed.
关键词：dichloromethyl alkyl ether;fluorobenzaldehyde;aryl formate;fluoroanisole;fluorophenol;Lewis acid