文章基本信息

标题：Development of Novel Functional Molecules Targeting DNA and RNA
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作者：Shigeki Sasaki
期刊名称：Chemical and Pharmaceutical Bulletin
印刷版ISSN：0009-2363
电子版ISSN：1347-5223
出版年度：2019
卷号：67
期号：6
页码：505-518
DOI：10.1248/cpb.c19-00169
出版社：The Pharmaceutical Society of Japan
摘要：Nucleic acid therapeutics such as antisense and small interfering RNA (siRNA) have attracted increasing attention as innovative medicines that interfere with and/or modify gene expression systems. We have developed new functional oligonucleotides that can target DNA and RNA with high efficiency and selectivity. This review summarizes our achievements, including (1) the formation of non-natural triplex DNA for sequence-specific inhibition of transcription; (2) artificial receptor molecules for 8-oxidized-guanosine nucleosides; and (3) reactive oligonucleotides with a cross-linking agent or a functionality-transfer nucleoside for RNA pinpoint modification.
关键词：genome-targeting;non-natural triplex DNA;artificial receptor;8-oxidized-guanosine;cross-link formation;functionality-transfer reaction