文章基本信息

标题：The Cdk1/Cdk2 homolog CDKA;1 controls the recombination landscape in Arabidopsis
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作者：Erik Wijnker ; Hirofumi Harashima ; Katja Müller 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2019
卷号：116
期号：25
页码：12534-12539
DOI：10.1073/pnas.1820753116
出版社：The National Academy of Sciences of the United States of America
摘要：Little is known how patterns of cross-over (CO) numbers and distribution during meiosis are established. Here, we reveal that cyclin-dependent kinase A;1 (CDKA;1), the homolog of human Cdk1 and Cdk2, is a major regulator of meiotic recombination in Arabidopsis . Arabidopsis plants with reduced CDKA;1 activity experienced a decrease of class I COs, especially lowering recombination rates in centromere-proximal regions. Interestingly, this reduction of type I CO did not affect CO assurance, a mechanism by which each chromosome receives at least one CO, resulting in all chromosomes exhibiting similar genetic lengths in weak loss-of-function cdka ;1 mutants. Conversely, an increase of CDKA;1 activity resulted in elevated recombination frequencies. Thus, modulation of CDKA;1 kinase activity affects the number and placement of COs along the chromosome axis in a dose-dependent manner.
关键词：meiosis ; cyclin-dependent kinase ; cross-over interference ; class I cross-overs ; meiotic recombination