首页    期刊浏览 2024年12月06日 星期五
登录注册

文章基本信息

  • 标题:Ligand binding pocket of a novel Allatostatin receptor type C of stick insect, Carausius morosus
  • 本地全文:下载
  • 作者:Burcin Duan Sahbaz ; Osman Ugur Sezerman ; Hamdi Torun
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2017
  • 卷号:7
  • 期号:1
  • DOI:10.1038/srep41266
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:Allatostatins (AST) are neuropeptides with variable function ranging from regulation of developmental processes to the feeding behavior in insects. They exert their effects by binding to cognate GPCRs, called Allatostatin receptors (AlstR), which emerge as promising targets for pesticide design. However, AlstRs are rarely studied. This study is the first reported structural study on AlstR-AST interaction. In this work, the first C type AlstR from the stick insect Carausius morosus (CamAlstR-C) was identified and its interaction with type C AST peptide was shown to be physically consistent with the experimental results. The proposed structure of CamAlstR-C revealed a conserved motif within the third extracellular loop, which, together with the N-terminus is essential for ligand binding. In this work, computational studies were combined with molecular and nano-scale approaches in order to introduce an unknown GPCR-ligand system. Consequently, the data obtained provided a reliable target region for future agonist/inverse agonist studies on AlstRs.
国家哲学社会科学文献中心版权所有