文章基本信息

标题：Non-invasive, Focused Ultrasound-Facilitated Gene Delivery for Optogenetics
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作者：Shutao Wang ; Tara Kugelman ; Amanda Buch 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2017
卷号：7
期号：1
DOI：10.1038/srep39955
语种：English
出版社：Springer Nature
摘要：Optogenetics, a widely used technique in neuroscience research, is often limited by its invasive nature of application. Here, we present a noninvasive, ultrasound-based technique to introduce optogenetic channels into the brain by temporarily opening the blood-brain barrier (BBB). We demonstrate the efficiency of the method developed and evaluate the bioactivity of the non-invasively introduced channelrhodopsin channels by performing stimulation in freely behaving mice.