文章基本信息

标题：Loss of Calreticulin Uncovers a Critical Role for Calcium in Regulating Cellular Lipid Homeostasis
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作者：Wen-An Wang ; Wen-Xin Liu ; Serpen Durnaoglu 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2017
卷号：7
期号：1
DOI：10.1038/s41598-017-05734-x
语种：English
出版社：Springer Nature
摘要：A direct link between Ca(2+) and lipid homeostasis has not been definitively demonstrated. In this study, we show that manipulation of ER Ca(2+) causes the re-distribution of a portion of the intracellular unesterified cholesterol to a pool that is not available to the SCAP-SREBP complex. The SREBP processing pathway in ER Ca(2+) depleted cells remained fully functional and responsive to changes in cellular cholesterol status but differed unexpectedly in basal activity. These findings establish the role of Ca(2+) in determining the reference set-point for controlling cellular lipid homeostasis. We propose that ER Ca(2+) status is an important determinant of the basal sensitivity of the sterol sensing mechanism inherent to the SREBP processing pathway.