文章基本信息

标题：Complexity analysis of fNIRS signals in ADHD children during working memory task
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作者：Yue Gu ; Shuo Miao ; Junxia Han 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2017
卷号：7
期号：1
DOI：10.1038/s41598-017-00965-4
语种：English
出版社：Springer Nature
摘要：Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder in children. Neuroimaging studies have revealed abnormalities of neural activities in some brain regions, including the frontal cortex, striatum, cerebellum, and occipital cortex. Recently, some investigators have demonstrated that nonlinear complexity analysis of neural activity may provide a new index to indicate ADHD. In the present study, we used the permutation entropy (PE) to measure the complexity of functional near-infrared spectroscopy (fNIRS) signals in children with and without ADHD during a working memory task, it was aimed to investigate the relationship between the PE values and the cortical activations, and the different PE values between the children with and without ADHD. We found that PE values exhibited significantly negative correlation with the cortical activations (r = -0.515, p = 0.003), and the PE values of right dorsolateral prefrontal cortex in ADHD children were significantly larger than those in normal controls (p = 0.027). In addition, the PE values of right dorsolateral prefrontal cortex were positively correlated to the ADHD index (r = 0.448, p = 0.012). These results suggest that complexity analysis of fNIRS signals could be a promising tool in diagnosing children with ADHD.