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  • 标题:Intubation-free in vivo imaging of the tracheal mucosa using two-photon microscopy
  • 本地全文:下载
  • 作者:Tibor Z. Veres ; Tamás Kopcsányi ; Marko Tirri
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2017
  • 卷号:7
  • 期号:1
  • DOI:10.1038/s41598-017-00769-6
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:The mucosal layer of conducting airways is the primary tissue exposed to inhaled microorganisms, allergens and pollutants. We developed an in vivo two-photon microscopic approach that allows performing dynamic imaging studies in the mouse trachea, which is a commonly used in vivo model of human small-diameter bronchi. By providing stabilized access to the tracheal mucosa without intubation, our setup uniquely allows dynamic in vivo imaging of mucociliary clearance and steady-state immune cell behavior within the complex airway mucosal tissue.
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