文章基本信息

标题：The Cipher Code of Simple Sequence Repeats in “Vampire Pathogens”
本地全文：下载
作者：Geng Zou ; Bernardo Bello-Orti ; Virginia Aragon 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2015
卷号：5
期号：1
DOI：10.1038/srep12441
语种：English
出版社：Springer Nature
摘要：Blood inside mammals is a forbidden area for the majority of prokaryotic microbes; however, red blood cells tropism microbes, like “vampire pathogens” (VP), succeed in matching scarce nutrients and surviving strong immunity reactions. Here, we found VP of Mycoplasma , Rhizobiales , and Rickettsiales showed significantly higher counts of (AG)_n dimeric simple sequence repeats (Di-SSRs) in the genomes, coding and non-coding regions than non Vampire Pathogens (N_VP). Regression analysis indicated a significant correlation between GC content and the span of (AG)_n-Di-SSR variation. Gene Ontology (GO) terms with abundance of (AG)₃-Di-SSRs shared by the VP strains were associated with purine nucleotide metabolism ( FDR 0.01), indicating an adaptation to the limited availability of purine and nucleotide precursors in blood. Di-amino acids coded by (AG)_n-Di-SSRs included all three six-fold code amino acids (Arg, Leu and Ser) and significantly higher counts of Di-amino acids coded by (AG)₃, (GA)₃, and (TC)₃ in VP than N_VP. Furthermore, significant differences ( P 0.001) on the numbers of triplexes formed from (AG)_n-Di-SSRs between VP and N_VP in Mycoplasma suggested the potential role of (AG)_n-Di-SSRs in gene regulation.