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标题：Glucocorticoid (dexamethasone)-induced metabolome changes in healthy males suggest prediction of response and side effects
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作者：Natalie Bordag ; Sebastian Klie ; Kathrin Jürchott 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2015
卷号：5
期号：1
DOI：10.1038/srep15954
语种：English
出版社：Springer Nature
摘要：Glucocorticoids are indispensable anti-inflammatory and decongestant drugs with high prevalence of use at ^~0.9% of the adult population. Better holistic insights into glucocorticoid-induced changes are crucial for effective use as concurrent medication and management of adverse effects. The profiles of 214 metabolites from plasma of 20 male healthy volunteers were recorded prior to and after ingestion of a single dose of 4 mg dexamethasone (+20 mg pantoprazole). Samples were drawn at three predefined time points per day: seven untreated (day 1 midday - day 3 midday) and four treated (day 3 evening - day 4 evening) per volunteer. Statistical analysis revealed tremendous impact of dexamethasone on the metabolome with 150 of 214 metabolites being significantly deregulated on at least one time point after treatment (ANOVA, Benjamini-Hochberg corrected, q