文章基本信息

标题：Convertible MRI contrast: Sensing the delivery and release of anti-glioma nano-drugs
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作者：Liang Zhang ; Zhongwei Zhang ; Ralph P. Mason 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2015
卷号：5
期号：1
DOI：10.1038/srep09874
语种：English
出版社：Springer Nature
摘要：There is considerable interest in developing nanohybrids of imaging contrast agents and drugs for image-guided drug delivery. We have developed a strategy of utilizing manganese (Mn) to enhance the nano-encapsulation of arsenic trioxide (ATO). Formation of arsenite (As³⁺)-Mn precipitates in liposomes generates magnetic susceptibility effects, reflected as dark contrast on T₂-weighted MRI. Intriguingly, following cell uptake, the As-Mn complex decomposes in response to low pH in endosome-lysosome releasing ionic As³⁺, the active form of ATO, and Mn²⁺, the T₁ contrast agent that gives a bright signal. Glioblastoma (GBM) is well known for its high resistance to chemotherapy, e.g., temozolomide (TMZ). Building upon the previously established phosphatidylserine (PS)-targeted nanoplatform that has excellent GBM-targeting specificity, we now demonstrate the effectiveness of the targeted nanoformulated ATO for treating TMZ-resistant GBM cells and the ability of the convertible Mn contrast as a surrogate revealing the delivery and release of ATO.