文章基本信息

标题：Modular Design of the Selectivity Filter Pore Loop in a Novel Family of Prokaryotic ‘Inward Rectifier’ (NirBac) channels
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作者：Lejla Zubcevic ; Shizhen Wang ; Vassiliy N. Bavro 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2015
卷号：5
期号：1
DOI：10.1038/srep15305
语种：English
出版社：Springer Nature
摘要：Potassium channels exhibit a modular design with distinct structural and functional domains; in particular, a highly conserved pore-loop sequence that determines their ionic selectivity. We now report the functional characterisation of a novel group of functionally non-selective members of the prokaryotic ‘inward rectifier’ subfamily of K⁺ channels. These channels share all the key structural domains of eukaryotic and prokaryotic Kir/KirBac channels, but instead possess unique pore-loop selectivity filter sequences unrelated to any other known ionic selectivity filter. The strikingly unusual architecture of these ‘NirBac’ channels defines a new family of functionally non-selective ion channels, and also provides important insights into the modular design of ion channels, as well as the evolution of ionic selectivity within this superfamily of tetrameric cation channels.