文章基本信息

标题：Sound Packing DNA: packing open circular DNA with low-intensity ultrasound
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作者：DongHee Park ; Bong-Kwang Jung ; Hyunjin Park 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2015
卷号：5
期号：1
DOI：10.1038/srep09846
语种：English
出版社：Springer Nature
摘要：Supercoiling DNA (folding DNA into a more compact molecule) from open circular forms requires significant bending energy. The double helix is coiled into a higher order helix form; thus it occupies a smaller footprint. Compact packing of DNA is essential to improve the efficiency of gene delivery, which has broad implications in biology and pharmaceutical research. Here we show that low-intensity pulsed ultrasound can pack open circular DNA into supercoil form. Plasmid DNA subjected to 5.4 mW/cm² intensity ultrasound showed significant (p-values