文章基本信息

标题：Involvement of PrPC in kainate-induced excitotoxicity in several mouse strains
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作者：Patricia Carulla ; Franc Llorens ; Andreu Matamoros-Angles 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2015
卷号：5
期号：1
DOI：10.1038/srep11971
语种：English
出版社：Springer Nature
摘要：The cellular prion protein (PrP^C) has been associated with a plethora of cellular functions ranging from cell cycle to neuroprotection. Mice lacking PrP^C show an increased susceptibility to epileptic seizures; the protein, then, is neuroprotective. However, lack of experimental reproducibility has led to considering the possibility that other factors besides PrP^C deletion, such as the genetic background of mice or the presence of so-called “ Prnp flanking genes”, might contribute to the reported susceptibility. Here, we performed a comparative analysis of seizure-susceptibility using characterized Prnp ^+/+ and Prnp ^0/0 mice of B6129, B6.129, 129/Ola or FVB/N genetic backgrounds. Our study indicates that PrP^C plays a role in neuroprotection in KA-treated cells and mice. For this function, PrP^C should contain the aa32–93 region and needs to be linked to the membrane. In addition, some unidentified “ Prnp -flanking genes” play a role parallel to PrP^C in the KA-mediated responses in B6129 and B6.129 Prnp ^0/0 mice.