文章基本信息

标题：The Galvanotactic Migration of Keratinocytes is Enhanced by Hypoxic Preconditioning
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作者：Xiaowei Guo ; Xupin Jiang ; Xi Ren 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2015
卷号：5
期号：1
DOI：10.1038/srep10289
语种：English
出版社：Springer Nature
摘要：The endogenous electric field (EF)-directed migration of keratinocytes (galvanotaxis) into wounds is an essential step in wound re-epithelialization. Hypoxia, which occurs immediately after injury, acts as an early stimulus to initiate the healing process; however, the mechanisms for this effect, remain elusive. We show here that the galvanotactic migration of keratinocytes was enhanced by hypoxia preconditioning as a result of the increased directionality rather than the increased motility of keratinocytes. This enhancement was both oxygen tension- and preconditioning time-dependent, with the maximum effects achieved using 2% O₂ preconditioning for 6 hours. Hypoxic preconditioning (2% O₂, 6 hours) decreased the threshold voltage of galvanotaxis to