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标题：Coffee consumption and risk of endometrial cancer: a dose-response meta-analysis of prospective cohort studies
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作者：Quan Zhou ; Mei-Ling Luo ; Hui Li 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2015
卷号：5
期号：1
DOI：10.1038/srep13410
语种：English
出版社：Springer Nature
摘要：This is a dose-response (DR) meta-analysis to evaluate the association of coffee consumption on endometrial cancer (EC) risk. A total 1,534,039 participants from 13 published articles were added in this meta-analysis. The RR of total coffee consumption and EC were 0.80 (95% CI : 0.74–0.86). A stronger association between coffee intake and EC incidence was found in patients who were never treated with hormones, 0.60 (95% CI : 0.50–0.72), and subjects with a BMI ≥25 kg/m², 0.57 (95% CI : 0.46–0.71). The overall RRs for caffeinated and decaffeinated coffee were 0.66 (95% CI : 0.52–0.84) and 0.77 (95% CI : 0.63–0.94), respectively. A linear DR relationship was seen in coffee, caffeinated coffee, decaffeinated coffee and caffeine intake. The EC risk decreased by 5% for every 1 cup per day of coffee intake, 7% for every 1 cup per day of caffeinated coffee intake, 4% for every 1 cup per day of decaffeinated intake of coffee, and 4% for every 100 mg of caffeine intake per day. In conclusion, coffee and intake of caffeine might significantly reduce the incidence of EC, and these effects may be modified by BMI and history of hormone therapy.