文章基本信息

标题：Infants born large-for-gestational-age display slower growth in early infancy, but no epigenetic changes at birth
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作者：Valentina Chiavaroli ; Wayne S. Cutfield ; José G. B. Derraik 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2015
卷号：5
期号：1
DOI：10.1038/srep14540
语种：English
出版社：Springer Nature
摘要：We evaluated the growth patterns of infants born large-for-gestational-age (LGA) from birth to age 1 year compared to those born appropriate-for-gestational-age (AGA). In addition, we investigated possible epigenetic changes associated with being born LGA. Seventy-one newborns were classified by birth weight as AGA (10^th–90^th percentile; n = 42) or LGA (>90^th percentile; n = 29). Post-natal follow-up until age 1 year was performed with clinical assessments at 3, 6, and 12 months. Genome-wide DNA methylation was analysed on umbilical tissue in 19 AGA and 27 LGA infants. At birth, LGA infants had greater weight (p