文章基本信息

标题：CD4+CD25+ cells in multiple myeloma related renal impairment
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作者：Hongdong Huang ; Yang Luo ; Yumei Liang 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2015
卷号：5
期号：1
DOI：10.1038/srep16565
语种：English
出版社：Springer Nature
摘要：CD4⁺CD25⁺ cells are critical regulators in almost all of the animal models of human organ-specific autoimmune diseases, transplant rejection and allergic diseases. We aimed to explore the role of CD4⁺CD25⁺ cells in the pathogenesis of multiple myeloma (MM) related renal impairment (RI). Thirty patients with MM related RI and 30 healthy volunteers were studied. The number of CD4⁺CD25⁺ cells was examined by flow cytometry. Clinical and laboratory data were collected from each subject. Glomerular injury was assessed by histopathology. Serum IL-2, IL-4 and IL-6 were analyzed by ELISA. CD4⁺CD25⁺ cells significantly decreased in MM related RI patients compared to the controls ( P +CD25⁺ cell number was negatively associated with blood urea nitrogen (BUN), supernatant IL-4, serum IL-6, monoclonal immunoglobulin and β2-microglobulin, as well as bone marrow plasma cell percentage and proteinuria; whereas positively associated with estimated glomerular filtration rate (eGFR) (all P +CD25⁺ cells gradually decreased as the Clinic Stage increased. The number of CD4⁺CD25⁺ cells reduced in MM related RI patients, and was correlated with disease severity. CD4⁺CD25⁺ cells may play an important role in the pathogenesis of MM related RI.