文章基本信息

标题：The Nuclear Receptor Nr4a1 Controls CD8 T Cell Development Through Transcriptional Suppression of Runx3
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作者：Heba N. Nowyhed ; Tridu R. Huynh ; Amy Blatchley 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2015
卷号：5
期号：1
DOI：10.1038/srep09059
语种：English
出版社：Springer Nature
摘要：The NR4A nuclear receptor family member Nr4a1 is strongly induced in thymocytes undergoing selection, and has been shown to control the development of T_reg cells; however the role of Nr4a1 in CD8⁺ T cells remains undefined. Here we report a novel role for Nr4a1 in regulating the development and frequency of CD8⁺ T cells through direct transcriptional control of Runx3 . We discovered that Nr4a1 recruits the corepressor, CoREST to suppress Runx3 expression in CD8⁺ T cells. Loss of Nr4a1 results in increased Runx3 expression in thymocytes which consequently causes a 2-fold increase in the frequency and total number of intrathymic and peripheral CD8⁺ T cells. Our findings establish Nr4a1 as a novel and critical player in the regulation of CD8 T cell development through the direct suppression of Runx3 .