文章基本信息

标题：Thumb Imprint Based Detection of Hyperbilirubinemia Using Luminescent Gold Nanoclusters
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作者：Srestha Basu ; Amaresh Kumar Sahoo ; Anumita Paul 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2016
卷号：6
期号：1
DOI：10.1038/srep39005
语种：English
出版社：Springer Nature
摘要：Early and easy detection of diseases, using point-of-care and inexpensive devices, not only provides option for early treatment but also reduces the risk of propagation. Herein we report the fabrication of a robust film based luminescence indicator of bilirubin, which can indicate hyperbilirubinemia through the thumb imprint of the patient. The UV-light induced luminescence intensity of the film, made out of chitosan stabilised gold (Au) nanoclusters, which was effectively quenched in the presence of Cu(2+) ions, recovered in the presence of bilirubin from skin or blood serum. Moreover, the sensitivity of detection of bilirubin was tuneable with the amount of Cu(2+) added, thereby facilitating the detection of the desired concentration range of bilirubin.