文章基本信息

标题：Quantifying the cooperative subunit action in a multimeric membrane receptor
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作者：Nisa Wongsamitkul ; Vasilica Nache ; Thomas Eick 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2016
卷号：6
期号：1
DOI：10.1038/srep20974
语种：English
出版社：Springer Nature
摘要：In multimeric membrane receptors the cooperative action of the subunits prevents exact knowledge about the operation and the interaction of the individual subunits. We propose a method that permits quantification of ligand binding to and activation effects of the individual binding sites in a multimeric membrane receptor. The power of this method is demonstrated by gaining detailed insight into the subunit action in olfactory cyclic nucleotide-gated CNGA2 ion channels.