文章基本信息

标题：Tumor necrosis factor-α G-308A (rs1800629) polymorphism and aggressive periodontitis susceptibility: a meta-analysis of 16 case-control studies
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作者：Xue-Mei Wei ; Yong-Ji Chen ; Lan Wu 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2016
卷号：6
期号：1
DOI：10.1038/srep19099
语种：English
出版社：Springer Nature
摘要：Association between tumor necrosis factor-α (TNF-α) G-308A (rs1800629) polymorphism and susceptibility to aggressive periodontitis (AgP) were inconsistent, hence we performed this meta-analysis to clarify the association between them using Comprehensive Meta-Analysis v2.2 software. 16 case-control studies were searched from the PubMed, Embase and CNKI databases up to February 2, 2015. The meta-analysis showed a significantly increased risk in A vs. G ( OR = 1.23, 95% CI = 1.04–1.44), AA vs. GG ( OR = 2.07, 95% CI = 1.11–3.87), and AA vs. AG+GG genetic models ( OR = 2.09, 95% CI = 1.13–3.86); however, the non-significantly increased risk was shown in AG vs. GG ( OR = 1.06, 95% CI = 0.85–1.32) and AA+AG vs. GG genetic models ( OR = 1.06, 95% CI = 0.85–1.31). Cumulative analysis showed that the association changed from non-significant to significant with new studies accumulated and the CIs became more and more narrow, sensitivity analysis indicated results were statistically robust. Stratified analyses of confirmed of HWE, Asians, Caucasians, and population-based controls obtained results similar to that of overall analysis. There was no evidence of publication bias. In summary, current evidence demonstrates that TNF-a G-308A polymorphism might be associated with AgP susceptibility, especially in Asians and Caucasians.