文章基本信息

标题：Visualisation of newly synthesised collagen in vitro and in vivo
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作者：Corien Oostendorp ; Peter J.E. Uijtdewilligen ; Elly M. Versteeg 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2016
卷号：6
期号：1
DOI：10.1038/srep18780
语种：English
出版社：Springer Nature
摘要：Identifying collagen produced de novo by cells in a background of purified collagenous biomaterials poses a major problem in for example the evaluation of tissue-engineered constructs and cell biological studies to tumor dissemination. We have developed a universal strategy to detect and localize newly deposited collagen based on its inherent association with dermatan sulfate. The method is applicable irrespective of host species and collagen source.