首页    期刊浏览 2024年12月11日 星期三
登录注册

文章基本信息

  • 标题:The potential of GPNMB as novel neuroprotective factor in amyotrophic lateral sclerosis
  • 本地全文:下载
  • 作者:Hirotaka Tanaka ; Masamitsu Shimazawa ; Masataka Kimura
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2012
  • 卷号:2
  • 期号:1
  • DOI:10.1038/srep00573
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:

    Amyotrophic lateral sclerosis (ALS) is an incurable and fatal neurodegenerative disease characterized by the loss of motor neurons. Despite substantial research, the causes of ALS remain unclear. Glycoprotein nonmetastatic melanoma protein B (GPNMB) was identified as an ALS-related factor using DNA microarray analysis with mutant superoxide dismutase (SOD1G93A) mice. GPNMB was greatly induced in the spinal cords of ALS patients and a mouse model as the disease progressed. It was especially expressed in motor neurons and astrocytes. In an NSC34 cell line, glycosylation of GPNMB was inhibited by interaction with SOD1G93A, increasing motor neuron vulnerability, whereas extracellular fragments of GPNMB secreted from activated astrocytes attenuated the neurotoxicity of SOD1G93A in neural cells. Furthermore, GPNMB expression was substantial in the sera of sporadic ALS patients than that of other diseased patients. This study suggests that GPNMB can be a target for therapeutic intervention for suppressing motor neuron degeneration in ALS.

    .

    © 2012 Macmillan Publishers Limited. All rights reserved

国家哲学社会科学文献中心版权所有