文章基本信息

标题：Genome-wide survey of interindividual differences of RNA stability in human lymphoblastoid cell lines
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作者：Jubao Duan ; Jianxin Shi ; Xijin Ge 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2013
卷号：3
期号：1
DOI：10.1038/srep01318
语种：English
出版社：Springer Nature
摘要：The extent to which RNA stability differs between individuals and its contribution to the interindividual expression variation remain unknown. We conducted a genome-wide analysis of RNA stability in seven human HapMap lymphoblastoid cell lines (LCLs) and analyzed the effect of DNA sequence variation on RNA half-life differences. Twenty-six percent of the expressed genes exhibited RNA half-life differences between LCLs at a false discovery rate (FDR)