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  • 标题:Next-generation sequencing of the mitochondrial genome and association with IgA nephropathy in a renal transplant population
  • 本地全文:下载
  • 作者:Adam P. Douglas ; Dwaine R. Vance ; Elaine M. Kenny
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2015
  • 卷号:4
  • 期号:1
  • DOI:10.1038/srep07379
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:Kidneys are highly aerobic organs that are critically dependent on the normal functioning of mitochondria. Genetic variations disrupting mitochondrial function are associated with multifactorial disorders including kidney disease. This study sequenced the entire mitochondrial genome in a renal transplant cohort of 64 individuals, using next-generation sequencing, to evaluate the association of genetic variants with IgA nephropathy and end-stage renal disease (ESRD, n = 100).
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