文章基本信息

标题：Baicalin, a metabolite of baicalein with antiviral activity against dengue virus
本地全文：下载
作者：Ehsan Moghaddam ; Boon-Teong Teoh ; Sing-Sin Sam 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2015
卷号：4
期号：1
DOI：10.1038/srep05452
语种：English
出版社：Springer Nature
摘要：Baicalin, a flavonoid derived from Scutellaria baicalensis , is the main metabolite of baicalein released following administration in different animal models and human. We previously reported the antiviral activity of baicalein against dengue virus (DENV). Here, we examined the anti-DENV properties of baicalin in vitro , and described the inhibitory potentials of baicalin at different steps of DENV-2 (NGC strain) replication. Our in vitro antiviral experiments showed that baicalin inhibited virus replication at IC₅₀ = 13.5 ± 0.08 μg/ml with SI = 21.5 following virus internalization by Vero cells. Baicalin exhibited virucidal activity against DENV-2 extracellular particles at IC₅₀ = 8.74 ± 0.08 μg/ml and showed anti-adsorption effect with IC₅₀ = 18.07 ± 0.2 μg/ml. Our findings showed that baicalin as the main metabolite of baicalein exerting in vitro anti-DENV activity. Further investigations on baicalein and baicalin to deduce its antiviral therapeutic effects are warranted.