文章基本信息

标题：Bone Mineral Density and Cystic Fibrosis: A Review
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作者：Maryam Hassanzad ; Poopak Farnia ; Ali Akbar Samadani 等
期刊名称：International Journal of Pediatrics
印刷版ISSN：2345-5047
电子版ISSN：2345-5055
出版年度：2019
卷号：7
期号：7
页码：9701-9710
DOI：10.22038/ijp.2019.38975.3325
出版社：Mashhad University of Medical Sciences
摘要：Cystic fibrosis (CF) is a common progressive genetic disorder among children which involves lungs, kidneys, intestine and liver. Apart from the significance of genetic factors, various environmental factors particularly bone mineral density are directly associated with CF. Remarkably, bone disease is appeared as a routine and common trait in long term CF survivors which implies that environmental parameters including calcium and vitamin D intake as well as drug inducement are the most important risk factors causing low bone mineral density. Conspicuously, absolute and notable treatment of cystic fibrosis associated to bone disorder must involve investigating the risk factors including the reduced intake of certain vitamins and minerals due to pancreatic inadequacy, modified hormone production, severe and chronic lung infection with increased ranges of bone function cytokines for a weak bone health situation. In this review, focus is on these considerable factors alongside the genetic factors in cystic fibrosis.
关键词：Cystic fibrosis; Low Bone Mineral Density; Genetic Factors; Vitamin D