文章基本信息

标题：Organophosphate Pesticide Metabolite Concentrations in Urine during Pregnancy and Offspring Nonverbal IQ at Age 6 Years
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作者：Todd A. Jusko ; Michiel A. van den Dries ; Anjoeka Pronk 等
期刊名称：Environmental Health Perspectives
印刷版ISSN：0091-6765
电子版ISSN：1552-9924
出版年度：2019
卷号：127
期号：1
页码：1-11
DOI：10.1289/EHP3024
出版社：OCR Subscription Services Inc
摘要：Background: Susceptibility to organophosphate (OP) pesticide neurotoxicity may be greatest during the prenatal period; however, previous studies have produced mixed findings concerning in utero OP pesticide exposure and child cognition. Objectives: Our objective was to determine whether maternal urinary concentrations of OP pesticide metabolites are inversely associated with child nonverbal IQ at 6 y of age and to examine potential effect measure modification by the PON1 gene. Methods: Data came from 708 mother–child pairs participating in the Generation R Study. Maternal urine concentrations of six dialkylphosphates (DAPs), collected at < 18 , 18–25, and > 25 weeks of gestation, were determined. Child nonverbal IQ was measured at 6 y of age using the Mosaics and Categories subtests from the Snijders-Oomen Nonverbal Intelligence Test–Revised. PON1 was determined in cord blood for 474 infants. Multiple linear regression models were fit to estimate the DAP–IQ associations and PON1 interactions. Results: Overall, associations between child nonverbal IQ and maternal DAP concentrations were small and imprecise, and these associations were inconsistent across urine sampling periods. Howover, for a 10-fold difference in total DAP concentration for the > 25 weeks of gestation samples, adjusted child nonverbal IQ was 3.9 points lower (95% CI: − 7.5 , − 0.3 ). Heterogeneity in the DAP–IQ association by PON1 gene allele status was not observed ( n = 474 ). Conclusions: Consistent evidence of an association between higher maternal urinary DAP concentrations and lower child IQ scores at 6 y of age was not observed. There was some evidence for an inverse relation of child nonverbal IQ and late pregnancy urinary DAPs, but the estimated association was imprecise. https://doi.org/10.1289/EHP3024