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标题：Effect of Nutrient and Micronutrient Intake on Chylomicron Production and Postprandial Lipemia
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作者：Charles Desmarchelier ; Patrick Borel ; Denis Lairon 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2019
卷号：11
期号：6
页码：1-30
DOI：10.3390/nu11061299
出版社：MDPI Publishing
摘要：Postprandial lipemia, which is one of the main characteristics of the atherogenic dyslipidemia with fasting plasma hypertriglyceridemia, low high-density lipoprotein cholesterol and an increase of small and dense low-density lipoproteins is now considered a causal risk factor for atherosclerotic cardiovascular disease and all-cause mortality. Postprandial lipemia, which is mainly related to the increase in chylomicron production, is frequently elevated in individuals at high cardiovascular risk such as obese or overweight patients, type 2 diabetic patients and subjects with a metabolic syndrome who share an insulin resistant state. It is now well known that chylomicron production and thus postprandial lipemia is highly regulated by many factors such as endogenous factors: circulating factors such as hormones or free fatty acids, genetic variants, circadian rhythms, or exogenous factors: food components, dietary supplements and prescription drugs. In this review, we focused on the effect of nutrients, micronutrients and phytochemicals but also on food structure on chylomicron production and postprandial lipemia.
关键词：carbohydrates; cardiovascular disease; cholesterol; fibers; food structure; lipids; polyphenols; proteins; triglycerides; vitamins carbohydrates ; cardiovascular disease ; cholesterol ; fibers ; food structure ; lipids ; polyphenols ; proteins ; triglycerides ; vitamins