文章基本信息

标题：How a well-adapting immune system remembers
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作者：Andreas Mayer ; Vijay Balasubramanian ; Aleksandra M. Walczak 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2019
卷号：116
期号：18
页码：8815-8823
DOI：10.1073/pnas.1812810116
出版社：The National Academy of Sciences of the United States of America
摘要：An adaptive agent predicting the future state of an environment must weigh trust in new observations against prior experiences. In this light, we propose a view of the adaptive immune system as a dynamic Bayesian machinery that updates its memory repertoire by balancing evidence from new pathogen encounters against past experience of infection to predict and prepare for future threats. This framework links the observed initial rapid increase of the memory pool early in life followed by a midlife plateau to the ease of learning salient features of sparse environments. We also derive a modulated memory pool update rule in agreement with current vaccine-response experiments. Our results suggest that pathogenic environments are sparse and that memory repertoires significantly decrease infection costs, even with moderate sampling. The predicted optimal update scheme maps onto commonly considered competitive dynamics for antigen receptors.
关键词：immune repertoire ; Bayesian prediction ; biophysics ; immune memory ; stochastic dynamics