文章基本信息

标题：Cyclodextrin-Based Molecular Accessories for Drug Discovery and Drug Delivery
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作者：Taishi Higashi
期刊名称：Chemical and Pharmaceutical Bulletin
印刷版ISSN：0009-2363
电子版ISSN：1347-5223
出版年度：2019
卷号：67
期号：4
页码：289-298
DOI：10.1248/cpb.c18-00735
出版社：The Pharmaceutical Society of Japan
摘要：Recently, active pharmaceutical ingredients (APIs) have been dramatically expanding from low-molecular weight drugs to peptides, proteins, antibodies, genes, oligonucleotides, cells, and machines. Therefore to develop pharmaceutical technologies and drug delivery systems (DDS) for these APIs, advanced molecules and novel concepts are needed. In this review, we introduce cyclodextrin-based supramolecular accessories such as molecular necklace, molecular earring, and intelligent molecular necklace, and describe their application for pharmaceutical technology and DDS. In addition, we also introduce utility of supramolecular accessories as antitumor drugs. Finally, we propose a new concept in pharmaceutical sciences termed as “supramolecular pharmaceutical sciences,” which combines pharmaceutical sciences and supramolecular chemistry. This concept could be useful for developing new ideas, methods, hypotheses, strategies, materials, and mechanisms in pharmaceutical sciences.
关键词：molecular accessory;supramolecular chemistry;supermolecule;supramolecular pharmaceutical sciences;cyclodextrin (CyD);drug delivery system (DDS)