首页    期刊浏览 2024年12月03日 星期二
登录注册

文章基本信息

  • 标题:Evolution of resilience in protein interactomes across the tree of life
  • 本地全文:下载
  • 作者:Marinka Zitnik ; Rok Sosič ; Marcus W. Feldman
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:2019
  • 卷号:116
  • 期号:10
  • 页码:4426-4433
  • DOI:10.1073/pnas.1818013116
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Phenotype robustness to environmental fluctuations is a common biological phenomenon. Although most phenotypes involve multiple proteins that interact with each other, the basic principles of how such interactome networks respond to environmental unpredictability and change during evolution are largely unknown. Here we study interactomes of 1,840 species across the tree of life involving a total of 8,762,166 protein–protein interactions. Our study focuses on the resilience of interactomes to network failures and finds that interactomes become more resilient during evolution, meaning that interactomes become more robust to network failures over time. In bacteria, we find that a more resilient interactome is in turn associated with the greater ability of the organism to survive in a more complex, variable, and competitive environment. We find that at the protein family level proteins exhibit a coordinated rewiring of interactions over time and that a resilient interactome arises through gradual change of the network topology. Our findings have implications for understanding molecular network structure in the context of both evolution and environment.
  • 关键词:protein–protein interaction networks ; molecular evolution ; ecology ; network resilience ; network rewiring
国家哲学社会科学文献中心版权所有