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标题：Self-regulation and the foraging gene (PRKG1) in humans
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作者：Andriy A. Struk ; Jhotisha Mugon ; Andrea Huston 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2019
卷号：116
期号：10
页码：4434-4439
DOI：10.1073/pnas.1809924116
出版社：The National Academy of Sciences of the United States of America
摘要：Foraging is a goal-directed behavior that balances the need to explore the environment for resources with the need to exploit those resources. In Drosophila melanogaster , distinct phenotypes have been observed in relation to the foraging gene ( for ), labeled the rover and sitter. Adult rovers explore their environs more extensively than do adult sitters. We explored whether this distinction would be conserved in humans. We made use of a distinction from regulatory mode theory between those who “get on with it,” so-called locomotors, and those who prefer to ensure they “do the right thing,” so-called assessors. In this logic, rovers and locomotors share similarities in goal pursuit, as do sitters and assessors. We showed that genetic variation in PRKG1 , the human ortholog of for , is associated with preferential adoption of a specific regulatory mode. Next, participants performed a foraging task to see whether genetic differences associated with distinct regulatory modes would be associated with distinct goal pursuit patterns. Assessors tended to hug the boundary of the foraging environment, much like behaviors seen in Drosophila adult sitters. In a patchy foraging environment, assessors adopted more cautious search strategies maximizing exploitation. These results show that distinct patterns of goal pursuit are associated with particular genotypes of PRKG1 , the human ortholog of for .
关键词：foraging gene ; self-regulation ; locomotion ; assessment ; PRKG1