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标题：Avaliação e otimização das condições de obtenção do ácido acetilsalicílico para fins didáticos
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作者：Leslie Tauany Schneider da Luz ; Sandra Inês Adams Angnes Gomes ; Marilei Casturina Mendes Sandri 等
期刊名称：Anales del Instituto de Investigaciones Estéticas
印刷版ISSN：0185-1276
电子版ISSN：1870-3062
出版年度：2019
卷号：30
期号：2
页码：54-69
DOI：10.22201/fq.18708404e.2019.2.67393
出版社：Instituto de Investigaciones Estéticas
摘要：The synthesis of acetylsalicylic acid (ASA) is widely used in experimental chemistry classes for the teaching of nucleophilic reactions and the process of purification by recrystallization. Considering the diversity of protocols available in the literature, with divergences in the experimental conditions, this work had as objective to optimize the time and temperature conditions of the ASA synthesis and, at the same time, to improve the chemical greenery of the process aiming at greater mass and energetic efficiency, according to with principles 1, 2 and 6 of Green Chemistry (GC). For this, the synthesis of ASA was proposed at temperatures of 40 ° C, 50 °C, 60 °C, 70 °C, 80 and 90 °C for 10, 20, 30 and 40 minutes of reaction. The results indicate that the ASA obtained in 20 minutes at 80 °C presented the best results: a good yield, 77.70 ± 0.01%, with melting point 133 °C -134 °C, with Experimental Mass Efficiency 24% and Environmental Factor E 3,10; the best energy metrics, Throughput 0,101 g min -1 , Time Intensity 9.869 min g -1 , Energy Intensity 0.073 Kw h g -1 and the lowest power consumption, 0.1485 KWh, an efficiency gain approximately 200 %, contributing mainly to improvements in P6 of GC.
关键词：Ácido acetilsalicílico; Eficiência Energética; Métricas de Massa; Ensino