文章基本信息

标题：Toxicological studies of a metabolite of Streptomyces species on Brine shrimp and Mice
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作者：Zakia Sultana Sathi ; Ranjan Kumar Barman ; M Anwarul Islam 等
期刊名称：TAJ: Journal of Teachers Association
印刷版ISSN：1019-8555
出版年度：2010
卷号：23
期号：1
页码：6-9
DOI：10.3329/taj.v23i1.41122
语种：English
出版社：Teachers Association of Rajshahi Medical College
摘要：The cytotoxic activity of the crude chloroform extract of Streptomyces species and a pure compound, 4-hydroxy nitrobenzene (ZS-3) isolated from chloroform extract was determined by brine shrimp lethality bioassay. The LD₅₀values of chloroform extract and compound (ZS-3) and ampicillin trihydrate were found to be 5.6, 6.6 and 5.0 μg ml^-1, respectively. The acute toxicity of the compound (ZS-3) was also performed on Swiss albino mice. The median acute toxicity value (LD₅₀) of ZS-3 was found to be 62 mg kg^-1. Thus the isolated compound ZS-3 seems to be safe for therapeutic use. TAJ 2010; 23(1): 6-9
关键词：Toxicological studies;Brine shrimp and Mice