文章基本信息

标题：Apoptose e sarcopenia do músculo esquelético no envelhecimento
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作者：Fabrício Azevedo Voltarelli ; Maria Alice Rostom de Mello ; José Alberto Ramos Duarte 等
期刊名称：Motriz. Journal of Physical Education. UNESP
印刷版ISSN：1980-6574
出版年度：2007
页码：137-144
DOI：10.5016/758
语种：Portuguese
出版社：UNESP - São Paulo State University
摘要：Although the exact mechanisms underlying sarcopenia are far to be unveiled, accumulating preclinical evidence suggests that an age-related acceleration of myocites loss via apoptosis might represent a key mechanism driving the onset and progression of muscle loss. Furthermore, increased levels of apoptosis have also been reported in old rats undergoing acute muscle atrophy subsequent to muscle unloading. Several signaling pathways of skeletal muscle apoptosis are currently under intensive investigation, with a particular focus on the role played by mitochondria. Here, we will review the most recent evidence regarding various pathways of muscle apoptosis and their modulation by several interventions.