文章基本信息

标题：Future drug delivery technologies: benchtop to industry
本地全文：下载
作者：Md Jasim Uddin ; Irin Sultana ; Ayesha Amin Nipa 等
期刊名称：IIUC Studies
印刷版ISSN：2408-8544
出版年度：2017
卷号：14
期号：1
页码：9-20
DOI：10.3329/iiucs.v14i1.37651
语种：English
出版社：International Islamic University Chittagong
摘要：Transmucosal buccal drug delivery system is considered as a future drug delivery technology, always assist to enhance patient compliance mainly for paediatric and geriatric community. The studies aim to develop buccal delivery for delivering a hydrophilic drug, flucloxacillin sodium, across the mucosal route. The buccal films are comprised of a bio-adhesive polymer, plasticizer and drug. Optimised films were characterised by measurement of weight, length and width, hardness, thickness, surface pH, moisture content and uptake, swelling study, folding resilience, hydration and entrapment efficiency. Drug release studies were performed for different polymer-plasticizer-drug ratios. Concentration of polymer and plasticizer were influenced on the development, evaluation and release rate of flucloxacillin sodium from the buccal films. In conclusion, these studies reveal that buccal delivery of flucloxacillin sodium can be an alternative route in comparison to conventional route for patient compliance. IIUC Studies Vol.14(1) June 2017: 09-20
其他摘要：Transmucosal buccal drug delivery system is considered as a future drug delivery technology, always assist to enhance patient compliance mainly for paediatric and geriatric community. The studies aim to develop buccal delivery for delivering a hydrophilic drug, flucloxacillin sodium, across the mucosal route. The buccal films are comprised of a bio-adhesive polymer, plasticizer and drug. Optimised films were characterised by measurement of weight, length and width, hardness, thickness, surface pH, moisture content and uptake, swelling study, folding resilience, hydration and entrapment efficiency. Drug release studies were performed for different polymer-plasticizer-drug ratios. Concentration of polymer and plasticizer were influenced on the development, evaluation and release rate of flucloxacillin sodium from the buccal films. In conclusion, these studies reveal that buccal delivery of flucloxacillin sodium can be an alternative route in comparison to conventional route for patient compliance.IIUC Studies Vol.14(1) June 2017: 09-20
关键词：Buccal delivery;Solvent casting;Drug release