文章基本信息

标题：Effects of HIV infection on CD4 + T-cell population based on a fractional-order model
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作者：Sadia Arshad ; Dumitru Baleanu ; Weiping Bu 等
期刊名称：Advances in Difference Equations
印刷版ISSN：1687-1839
电子版ISSN：1687-1847
出版年度：2017
卷号：2017
期号：1
页码：92
DOI：10.1186/s13662-017-1143-0
语种：English
出版社：Hindawi Publishing Corporation
摘要：In this paper, we study the HIV infection model based on fractional derivative with particular focus on the degree of T-cell depletion that can be caused by viral cytopathicity. The arbitrary order of the fractional derivatives gives an additional degree of freedom to fit more realistic levels of CD4+ cell depletion seen in many AIDS patients. We propose an implicit numerical scheme for the fractional-order HIV model using a finite difference approximation of the Caputo derivative. The fractional system has two equilibrium points, namely the uninfected equilibrium point and the infected equilibrium point. We investigate the stability of both equilibrium points. Further we examine the dynamical behavior of the system by finding a bifurcation point based on the viral death rate and the number of new virions produced by infected CD4+ T-cells to investigate the influence of the fractional derivative on the HIV dynamics. Finally numerical simulations are carried out to illustrate the analytical results.
关键词：fractional derivative ; HIV model ; finite difference scheme ; dynamical analysis