文章基本信息

标题：A model of HIV/AIDS population dynamics including ARV treatment and pre-exposure prophylaxis
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作者：Mozart U Nsuami ; Peter J Witbooi
期刊名称：Advances in Difference Equations
印刷版ISSN：1687-1839
电子版ISSN：1687-1847
出版年度：2018
卷号：2018
期号：1
页码：11
DOI：10.1186/s13662-017-1458-x
语种：English
出版社：Hindawi Publishing Corporation
摘要：Antiretroviral treatment (ART) and oral pre-exposure prophylaxis (PrEP) have recently been used efficiently in management of HIV infection. Pre-exposure prophylaxis consists in the use of an antiretroviral medication to prevent the acquisition of HIV infection by uninfected individuals. We propose a new model for the transmission of HIV/AIDS including ART and PrEP. Our model can be used to test the effects of ART and of the uptake of PrEP in a given population, as we demonstrate through simulations. The model can also be used to estimate future projections of HIV prevalence. We prove global stability of the disease-free equilibrium. We also prove global stability of the endemic equilibrium for the most general case of the model, i.e., which allows for PrEP individuals to default. We include insightful simulations based on recently published South-African data.
关键词：HIV/AIDS model ; basic reproduction number ; pre-exposure prophylaxis ; stability