文章基本信息

标题：Results and generalizability of the Target Temperature Management Trial and future research for patients admitted to intensive care after cardiac arrest
本地全文：下载
作者：Niklas Nielsen
期刊名称：BMC Emergency Medicine
印刷版ISSN：1471-227X
电子版ISSN：1471-227X
出版年度：2015
卷号：15
期号：1
页码：A3
DOI：10.1186/1471-227X-15-S1-A3
语种：English
出版社：BioMed Central
摘要：The Target Temperature Management (TTM) Trial randomized 950 unconscious, adult patients with return of spontaneous circulation after out-of-hospital cardiac arrest (CA) of presumed cardiac cause to strict temperature management at either 33°C or 36°C. Temperature was managed with intravascular or surface cooling devices for 36 hours, while the patients were sedated and mechanically ventilated. Prognostication and decisions on life-sustaining treatments were postponed until 4.5 to 5 days after CA in the general case [1]. There was no difference in the primary outcome: survival until the end of the trial (mortality 50% in the 33°C group and 48% in the 36°C group, hazard ratio 1.06, 95% confidence interval 0.89 to 1.28, p = 0.51) or the secondary outcomes: neurological function at 6 months and adverse events [2]. In a substudy with detailed cognitive assessment, the groups were similar [3].
关键词：Cardiac Arrest ; Cardiopulmonary Resuscitation ; Spontaneous Circulation ; Basic Life Support ; Temperature Management