文章基本信息

标题：The Effect of Omega-3 and Omega-6 Polyunsaturated Fatty Acids on the Production of Cyclooxygenase and Lipoxygenase Metabolites by Human Umbilical Vein Endothelial Cells
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作者：Pedro Araujo ; Ikram Belghit ; Niels Aarsæther 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2019
卷号：11
期号：5
DOI：10.3390/nu11050966
出版社：MDPI Publishing
摘要：Although the correlation between polyunsaturated fatty acids (PUFA) and the production of pro- and anti-inflammatory metabolites is well documented, little is known about the simultaneous effect of different PUFA on the production of cyclooxygenase and lipoxygenase metabolites. The present research examines the association between different omega-3 (ω-3) and omega-6 (ω-6) PUFA and the release of four cyclooxygenase and six lipoxygenase metabolites in cell medium by human umbilical vein endothelial cells (HUVEC). The different combinations of ω-3 and ω-6 PUFA were prepared according to a full 24 factorial design that enables studying not only the main effects but also the different interactions between fatty acids. In addition, interactions diagrams and principal component analysis were useful tools for interpreting higher order interactions. To the best of our knowledge, this is the first report addressing the combined effect of ω-3 and ω-6 PUFA on the signaling of prostaglandins, prostacyclins, leukotrienes and resolvins by HUVEC.
关键词：polyunsaturated fatty acids; docosahexaenoic acid; eicosapentaenoic acid; α-linolenic acid; arachidonic acid; human umbilical vein endothelial cells; eicosanoids; prostacyclins; leukotrienes; resolvins polyunsaturated fatty acids ; docosahexaenoic acid ; eicosapentaenoic acid ; α-linolenic acid ; arachidonic acid ; human umbilical vein endothelial cells ; eicosanoids ; prostacyclins ; leukotrienes ; resolvins