首页    期刊浏览 2024年12月05日 星期四
登录注册

文章基本信息

  • 标题:Protection of the Ovine Fetal Gut against Ureaplasma-Induced Chorioamnionitis: A Potential Role for Plant Sterols
  • 本地全文:下载
  • 作者:Charlotte van Gorp ; Ilse H. de Lange ; Owen B. Spiller
  • 期刊名称:Nutrients
  • 电子版ISSN:2072-6643
  • 出版年度:2019
  • 卷号:11
  • 期号:5
  • DOI:10.3390/nu11050968
  • 出版社:MDPI Publishing
  • 摘要:Chorioamnionitis, clinically most frequently associated with Ureaplasma, is linked to intestinal inflammation and subsequent gut injury. No treatment is available to prevent chorioamnionitis-driven adverse intestinal outcomes. Evidence is increasing that plant sterols possess immune-modulatory properties. Therefore, we investigated the potential therapeutic effects of plant sterols in lambs intra-amniotically (IA) exposed to Ureaplasma. Fetal lambs were IA exposed to Ureaplasma parvum (U. parvum, UP) for six days from 127 d–133 d of gestational age (GA). The plant sterols β-sitosterol and campesterol, dissolved with β-cyclodextrin (carrier), were given IA every two days from 122 d–131 d GA. Fetal circulatory cytokine levels, gut inflammation, intestinal injury, enterocyte maturation, and mucosal phospholipid and bile acid profiles were measured at 133 d GA (term 150 d). IA plant sterol administration blocked a fetal inflammatory response syndrome. Plant sterols reduced intestinal accumulation of proinflammatory phospholipids and tended to prevent mucosal myeloperoxidase-positive (MPO) cell influx, indicating an inhibition of gut inflammation. IA administration of plant sterols and carrier diminished intestinal mucosal damage, stimulated maturation of the immature epithelium, and partially prevented U. parvum-driven reduction of mucosal bile acids. In conclusion, we show that β-sitosterol and campesterol administration protected the fetus against adverse gut outcomes following UP-driven chorioamnionitis by preventing intestinal and systemic inflammation.
  • 关键词:chorioamnionitis; Ureaplasma parvum ; ovine; plant sterols; β-sitosterol; campesterol; fetal inflammatory response syndrome; intestinal inflammation; intestinal lipidome chorioamnionitis ; Ureaplasma parvum ; ovine ; plant sterols ; β-sitosterol ; campesterol ; fetal inflammatory response syndrome ; intestinal inflammation ; intestinal lipidome
国家哲学社会科学文献中心版权所有